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Document Type |
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Thesis |
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Document Title |
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Fabrication and evaluation of graphene quantum dots for thermal application تصنيع وتقييم نقاط الجرافين الكمومية للتطبيق الحراري |
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Subject |
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faculty of Pharmacy |
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Document Language |
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Arabic |
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Abstract |
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Nanotechnology is emerging as an important tool in cancer diagnosis and treatment. Novel nanomaterials are currently being developed to deliver anticancer agents to a specific site within the body, improving the targeting efficiency of drug delivery systems. One promising nanomaterial is nanosized graphene quantum dots (GQDs), which have the same chemical and physical properties as graphene. Another class of nanomaterial is silver nanoparticles (AgNPs), utilized as an anticancer and antibacterial agent. We synthesised graphene quantum dots (GQDs) and functionalized with silver to obtain silver Graphene quantum dots (Ag-GQDs). GQDs were synthesized from graphene using hydrothermal method, a top-down approach, by varying the reaction time and temperature to optimize particle size. The GQDs and Ag-GQDs were characterised physicochemically using Scanning electron microscopy (SEM), Transmission electron microscope (TEM), Fourier-transform infrared spectroscopy (FT-IR), UV-visible spectroscopy (UV-vis), X-ray diffraction (XRD), photoluminescence, and other techniques dynamic light scattering (DLS) analysis of particle size and zeta potential. The HR-TEM images of GQDs and Ag-GQDs revealed a size range of approximately 3-5 nm and 50-80 nm respectively. Cytotoxicity of GQDs and Ag- GQDs were evaluated in MCF-7 breast cancer cells in-vitro. Moreover, the results showed that the biocompatibility of Ag-GQDs was 5-fold more than GQDs.
Keywords: Graphene quantum dots, silver-functionalized graphene quantum dots, breast cancer, nanomaterials, hydrothermal technique, theranostic |
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Supervisor |
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Dr. Sapna cotta cotta |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1444 AH
2022 AD |
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Added Date |
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Tuesday, February 28, 2023 |
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Researchers
| نايف سمير باسبع | Basba, Nayef Samir | Researcher | Master | |
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