Document Details

Document Type : Thesis 
Document Title :
Functionalized single-walled carbon nanotubes as drug delivery for breast cancer treatment
تفعيل أنابيب النانو الكربونية أُحادية الجُدر كناقل دوائي لعلاج سرطان الثدي
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : Breast cancer has a major impact on health of women throughout the globe, being a second leading cause of cancer deaths after lung cancer. It is also one of the most imminent health problems in Saudi Arabia. The Single carbon nanotube (SWCNTs) has gained a momentum over the past decade as a suitable system for site-specific drug delivery and targeting. The main purpose of this study is to determine the bioavailability of SWCNTs as drug delivery vehicle for an ethyl acetate extract (EAESL) prepared from leaves of herbal medicine, Cassia angustifolia (Senna) so as to improve treatment of breast cancer. To achieve this goal, an EAESL combined to SWCNT was formulated (S-SWCNTs) and tried on the human breast cancer cells (MCF-7); then, the cell viability was assessed using MTT Assay. Giemsa stain and comet assay were utilized to monitor cellular alterations related to apoptotic cell death. Fluorescent stains, DCFH-DA and Jc-1, were implemented to assess levels of ROS generation and mitochondrial membrane potential, respectively. Treatment of MCF-7 cells with S-SWCNTs suppressed the proliferation and migration potential of the cells. Treated cells exhibited morphologic features of apoptotic cell death. S-SWCNTs induced DNA damage, an increase in ROS production and a decrease in mitochondrial membrane potential (MMP) in the treated cells. The findings in this study suggest that the S-SWCNTs provide important experimental facts for studying and developing novel strategies for fighting breast cancers. 
Supervisor : Dr. Majed Ahmad Al-shaeri 
Thesis Type : Master Thesis 
Publishing Year : 1440 AH
2019 AD 
Co-Supervisor : Prof. Ayman Ibrahim Elkady 
Added Date : Monday, August 19, 2019 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
صابرين محمد بحيريBehairy, Sabreen MohammedResearcherMaster 

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