Document Details

Document Type : Thesis 
Document Title :
VALUE OF RAISINS FOR REDUCTION OF OXIDATIVE STRESS IN CHRONIC INDUCED ANEMIA IN FEMALE RATS.
تعيين القيمه الغذائيه للزبيب في علاج الضغط الناتج عن الاكسده في اناث الفئران المصابه بالانيميا المزمنه المستحدثه معمليا
 
Subject : Faculty of medicine 
Document Language : Arabic 
Abstract : Vitamin D is part of many physiological functions in the body. This is enough reason to optimise vitamin D level in the body. Studies have linked vitamin D deficiency to the development of Gestational Diabetes Mellitus (GDM). It has been reported that platelet function and morphology was affected in patients with diabetes mellitus. Another study showed increase in mean platelet volume (MPV) with pregnant females suffering from GDM. As the above-mentioned variables have not been studied in a Saudi population we have aimed to compare Vitamin D levels in GDM and Non GDM pregnant women and also study the relation between MPV and Vitamin D level. Methods This cross sectional study was conducted at Obstetrics and Gynaecology outpatient clinic and inpatient obstetrics ward at King Abdulaziz University hospital, Jeddah, Saudi Arabia. From January to April 2016. 92 subjects who fulfilled the inclusion criteria were enrolled in the study. Data was collected by the main investigator. Written consent was obtained from all the subjects. Glucose Challenge Test (GCT) and Oral Glucose Tolerance Test (OGTT) were done for the subjects. Subjects were allocated to non-GDM (60 subjects) and GDM groups (32 subjects). Blood was obtained to measure 25 hydroxyvitamin D3 serum levels and mean platelet volume (MPV). According to the Vitamin D levels the subjects were divided into normal Vitamin D, insufficient Vitamin D, and deficient Vitamin D groups. Statistical analysis was done using SPSS. Results The most significant finding was a negative correlation between vitamin D level and glycosylated haemoglobin (HbA1c). Vitamin D level in the GDM group was less than the non GDM group without any statistical significance. All the 92 female patients were distributed into four quartiles depending on vitamin D level. They were arranged from lowest value to highest value of vitamin D. 30.4% of quartile 4 was GDM while 47.8 % of quartile 1 was GDM with no statistical significance. The incidence of GDM was higher in the first quartile as compared to the fourth quartile without any statistical significance. MPV was within the normal range. Conclusion Our study showed a negative correlation between vitamin D and HbA1C. It showed higher level of blood sugar parameters like GCT, GTTF, GTT1, GTT2 and GTT3 amongst the GDM group as compared to the non GDM Group. In the insufficient and deficient vitamin D groups the GDM subjects had a higher MPV compared to non GDM. In the normal vitamin D group, the non GDM group had a higher MPV than the GDM group. 
Supervisor : Dr. Azra Kirmani 
Thesis Type : Master Thesis 
Publishing Year : 1439 AH
2018 AD 
Added Date : Wednesday, May 2, 2018 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
دعاء محمد عبدالمجيدAbdulmajeed, Duaa MohammedResearcherMaster 

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