Document Details

Document Type : Article In Journal 
Document Title :
KIF19A is a microtubule-depolymerizing kinesin for ciliary length control
KIF19A is a microtubule-depolymerizing kinesin for ciliary length control
 
Document Language : English 
Abstract : Cilia control homeostasis of the mammalian body by generating fluid flow. It has long been assumed that ciliary length-control mechanisms are essential for proper flow generation, because fluid flow generation is a function of ciliary length. However, the molecular mechanisms of ciliary length control in mammals remain elusive. Here, we suggest that KIF19A, a member of the kinesin superfamily, regulates ciliary length by depolymerizing microtubules at the tips of cilia. Kif19a(-/-) mice displayed hydrocephalus and female infertility phenotypes due to abnormally elongated cilia that cannot generate proper fluid flow. KIF19A localized to cilia tips, and recombinant KIF19A controlled the length of microtubules polymerized from axonemes in vitro. KIF19A had ATP-dependent microtubule-depolymerizing activity mainly at the plus end of microtubules. Our results indicated a molecular mechanism of ciliary length regulation in mammals, which plays an important role in the maintenance of the mammalian body. 
ISSN : 1534-5807 
Journal Name : Developmental cell 
Volume : 23 
Issue Number : 6 
Publishing Year : 1433 AH
2012 AD 
Article Type : Article 
Added Date : Wednesday, March 9, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Shinsuke NiwaNiwa, Shinsuke Investigator  
Kazuo NakajimaNakajima, Kazuo Researcher  
Harukata MikiMiki, Harukata Researcher  
Yusuke MinatoMinato, Yusuke Researcher  
Doudou WangWang, Doudou Researcher  
Nobutaka HirokawaHirokawa, Nobutaka Researcher  

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