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Document Type |
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Thesis |
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Document Title |
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Vitamin D Status in Women Diagnosed with Polycystic Ovary Syndrome تقييم فيتامين د عند النساء المصابات بتكيس المبايض |
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Document Language |
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English |
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Abstract |
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Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder in women. It typically presents with symptoms of anovulation, associated with clinical and/or biochemical evidence of androgen excess. Typical biochemical features are raised serum concentrations of testosterone and elevation of serum luteinizing hormone (LH), particularly in anovulatory women.
Vitamin D is the "sunshine vitamin" that can play a very important role in dealing with PCOS and improving the overall health. Unfortunately, women with PCOS tend to have lower than adequate vitamin D levels. The assessment of vitamin D status and treatment of vitamin D deficiency with oral vitamin D supplements should become a routine component of clinical practice and preventive medicine. A possible mechanism by which vitamin D status may influence ovulatory function is through its purported effects on insulin sensitivity.
Vitamin D deficiency continues to be a worldwide problem. Therefore, this study was designed to evaluate vitamin D status in Saudi women with PCOS in relation to insulin resistance (IR). This has been investigated through studying the biochemical parameters in the serum (fasting serum glucose, fasting serum insulin, Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), intact-Parathyroid hormone (PTH) and [25(OH)D] ). Bone Mineral Density (BMD) was also measured by dual energy X-ray absorptiometry (DXA), at the lumbar spine (L1-L4) and mean femur neck.
Results of the present study found that no significant difference in serum [25(OH)D], serum intact-PTH and BMD values (spine L1-L4 and femur neck) of the studied women with or without PCOS.
The data showed that high prevalence of vitamin D deficiency as defined by serum 25(OH)D levels <25 nmol/L, was common among otherwise PCOS (58.3%) and control (44.4%) women, respectively, giving an overall deficiency rate of 51.4%.
This study showed that the waist circumference was significantly higher in the obese PCOS as compared to those in the obese control group. In this study a significant elevation of LH and LH/FSH level were observed in PCOS group compared to the control group. The results of the present study indicated that each PCOS subgroups showed no difference in serum glucose levels. The results showed that there was significant increased in IR in women with PCOS, as demonstrated by three different methods (fasting serum insulin, GIR and HOMA).
It appears that routine measurement of IR in PCOS women to differentiate them as either IR or non-IR could be of help in the fields of academic research and clinical practice. Women with IR are more likely to be obese. They also have lower LH, LH/FSH ratios. While IR does not effect on [25(OH)D], serum intact-PTH of PCOS women.
In conclusion, the present study has demonstrated that vitamin D deficiency is rather highly prevalent among Saudi women, with or without PCOS. It seems obvious that further studies are needed to address the best preventive practical measures to overcome vitamin D deficiency or insufficiency in Saudi women. |
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Supervisor |
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Jalaluddin A. Jalal Khan |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1432 AH
2011 AD |
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Number Of Pages |
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75 |
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Co-Supervisor |
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Mohammed Saleh M. Ardawi |
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Added Date |
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Tuesday, December 16, 2014 |
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Researchers
| مي محمد البيك | Albaik, Mai mohammed | Investigator | Master | |
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Files
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37643.pdf
| pdf | وكالة عملدة شؤون المكتبات شطر الطالبات |
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