Document Details

Document Type : Article In Journal 
Document Title :
CYTOTOXIC ACTIVITY OF BIOACTIVE FRACTIONS FROM PM 701.
السامة للخلايا النشاط الكسور النشطة بيولوجيا من الساعة 701.
 
Subject : CYTOTOXIC ACTIVITY OF BIOACTIVE FRACTIONS FROM PM 701. 
Document Language : English 
Abstract : The cytotoxic activity of PM 701 (a clean and sterile natural product) and fractions obtained thereof was assessed against human cancer cell lines, namely, hepatocellular carcinoma (HEPG2), colon carcinoma (HCT 116) and human glioma (U251) cells by using sulforhodamine B assay. PM 701 was extracted with methyl alcohol to give PMF fraction that was chromatographed on a Si gel column to yield seven fractions (frs: M2- M8). PMF and its sub-fractions demonstrated a variable and notably high cytotoxic activity against the tested cell lines (IC50 0.5-10 μg/mL). Fractions M2 and M5 were found to demonstrate the most potent activity against HEPG2 cell line (IC50 0.54 μg/mL for each), followed by fraction M8 (IC50 1.01 μg/mL). The effect of the different fractions against normal human foreskin cell line (HFS) was also evaluated. Isolation and identification of the active cytotoxic compounds are now in progress in our laboratories 
ISSN : 1579-4377 
Journal Name : Electronic Journal of Environmental, Agricultural and Food Chemistry 
Volume : 8 
Issue Number : 11 
Publishing Year : 1429 AH
2009 AD 
Article Type : Article 
Added Date : Saturday, March 5, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
فاتن خورشيدKhorshid, fathen ResearcherDoctorate 

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