Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Genotype and antiretroviral drug resistance of human immunodeficiency virus-1 in Saudi Arabia Genotype and antiretroviral drug resistance of human immunodeficiency virus-1 in Saudi Arabia |
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Subject |
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Genotype and antiretroviral drug resistance of human immunodeficiency virus-1 in Saudi Arabia |
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Document Language |
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English |
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Abstract |
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Objectives: To analyze antiretroviral drug resistance and
determine the genotype of human immunodeficiency
virus (HIV)-1 in Saudi patients by sequencing an
amplified region of the viral pol gene.
Methods: This retrospective study analyzed data from
plasma samples submitted for genotypic drug sensitivitymonitoring. Samples were analyzed at the Special
Infectious Agent Unit, King Fahd Medical Research
Center of King Abdulaziz University, Jeddah, Kingdom
of Saudi Arabia from August 2004 to June 2009. The
Viroseq2.5® kit (Celera/Abbott) was used with ABI
Prism 3100 sequencer. All patients were Saudi nationals
and were on antiretroviral therapy, some experiencing
treatment failure.
Results: Based on protease region (PR), genotypes of 63
samples were as follows: C:22, G:21, B:9, CRF02_AG:5,
D:3, A:1, F:1, and J:1. Based on reverse transcriptase
region (RT), genotypes were as follows: C:23, G:24,
B:9, CRF02_AG: 2, D:2, A:1, and F:1. Antiretroviral
susceptibility testing results were as follows: 52% of
the isolates were susceptible to all 3 major classes of
antiretroviral drugs used, 41% had mutations known
to confer high level resistance to one or more of the
nucleoside analogue reverse transcriptase inhibitors, 16%
had mutations known to confer high level resistance
to non-nucleoside analogues reverse transcriptase
inhibitors, 13% had mutations known to confer high
level resistance to one or more of the protease inhibitors
(PI). Most isolates were susceptible to 2 or at least one
class of antiretroviral, and only 3% of the isolates had |
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ISSN |
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1319-1004 |
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Journal Name |
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Medical Science Journal |
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Volume |
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31 |
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Issue Number |
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9 |
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Publishing Year |
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1431 AH
2010 AD |
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Article Type |
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Article |
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Added Date |
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Monday, January 24, 2011 |
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Researchers
| غازي عبداللطيف جمجوم | Jamjoom, Ghazi A. | Investigator | Doctorate | |
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