Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Circulating Levels Of Ghrelin, Leptin, Resistin And Tumor Necrosis Factor Alpha Are Novel Markers In Ulcerative Colitis Circulating Levels Of Ghrelin, Leptin, Resistin And Tumor Necrosis Factor Alpha Are Novel Markers In Ulcerative Colitis |
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Document Language |
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English |
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Abstract |
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Recently adipose tissue has been regarded as a real endocrine organ that secretes many hormones, collectively known as adipokines. It has been suggested that these adipokines could play an important role in modulating body metabolism, appetite and immuno-inflammatory response, which were considered among the hallmarks of acute phase of ulcerative colitis. The present work aimed to study the plasma levels of tumor necrosis factor alpha (TNF-α), resistin, leptin and ghrelin in patients with ulcerative colitis to clarify their role in the inflammatory process and the associated anorexia and body weight loss in those patients. The study was conducted on 40 patients with ulcerative colitis (UC). Who were subdivided into 2 subgroups, 20 patients with acute ulcerative colitis (AUC), and 20 patients with remission ulcerative colitis (RUC). In addition, 20 healthy control subjects served as control group. Plasma levels of leptin, ghrelin measured using radioimmunoassay technique while resistin and TNF-α were determined by enzyme linked immunosorbant assay (ELISA) technique. The results of the present study revealed significantly increased plasma levels of resistin, ghrelin and TNF- in patients with AUC compared to both control and RUC groups (P<0.001), with a non-significant difference between the last 2 groups , (P >0.05), whereas plasma leptin level was significantly decreased in patients with AUC compared to both control and RUC groups (P<0.001), with a non-significant difference between the latter 2 groups( P >0.05). Furthermore, the positive correlation between body mass index and leptin and negative correlation with ghrelin in AUC, confirmed their role in anorexia. Positive correlation between CRP and both resistin and ghrelin and negative correlation with leptin indicate that these adipokines correlated with severity of disease. On the basis of these results it could be concluded that adipokines could play a significant role in the pathogenesis of inflammatory processes and progress of ulcerative colitis and associated loss of weight |
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ISSN |
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1687-1502 |
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Journal Name |
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EJBMB |
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Volume |
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2 |
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Issue Number |
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4 |
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Publishing Year |
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2009 AH
2009 AD |
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Article Type |
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Article |
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Added Date |
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Saturday, May 15, 2010 |
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Researchers
| أسامة جابر | Gaber, Osama | Researcher | Doctorate | |
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