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Document Details
Document Type
:
Article In Journal
Document Title
:
METABOLIC CHANGES IN MELATONIN AND HIGH FAT DIET -TREATED RATS
METABOLIC CHANGES IN MELATONIN AND HIGH FAT DIET -TREATED RATS
Document Language
:
English
Abstract
:
This work was carried out to study the effect of melatonin on carbohydrate and lipid metabolism in male albino rats. Animals were divided into 4 groups. Control group, melatonin¬treated group, high fat fed-group, and high fat+melatonin treated group. Plasma glucose and insulin levels as well as glucose uptake by skeletal muscle (diaphragm) were assessed. In addition plasma lipoproteins profile as plasma triglycerides (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein- cholesterol (HDL-C) were also measured. Melatonin-treated+normally fed group showed significant hyperglycemia, while the changes in glucose uptake and plasma lipoproteins were statistically insignificant. On the other hand, melatonin administration to rats fed high fat diet resulted in significant hyperglycemia and significant decrease in glucose uptake together with significant reduction in plasma insulin level compared to diet matched group. Also melatonin resulted in significant reduction of TG, TC, and LDL-C associated with significant increase in HDL-C plasma levels. It is concluded that melatonin administration was associated with hyperglycemia, decrease glucose uptake and hypolipidemia. Such effect was marked when it is administered to rats on high fat diet.
ISSN
:
0940-5429
Journal Name
:
EGYPTIAN JOURNAL OF APPLIED ENDOCRINOLOGY
Volume
:
21
Issue Number
:
1
Publishing Year
:
2003 AH
2003 AD
Article Type
:
Article
Added Date
:
Sunday, March 21, 2010
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
عاطف موسى عبود
Abood, Atef M
Researcher
Doctorate
Files
File Name
Type
Description
26128.8
8
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