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Document Type |
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Article In Journal |
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Document Title |
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Ghrelin, Leptin, Insulin and Insulin Resistance in Newly Diagnosed Type 2 Diabetic Patients Ghrelin, Leptin, Insulin and Insulin Resistance in Newly Diagnosed Type 2 Diabetic Patients |
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Document Language |
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English |
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Abstract |
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Objectives: To evaluate the hormonal changes ghrelin, leptin, insulin and insulin resistance in newly diagnosed type 2 diabetic patients and their relation to metabolic state.
Methods: The present study was carried out on twenty newly diagnosed type 2 diabetic patients and fifteen apparently healthy persons as a control. Fasting plasma insulin, leptin, and ghrelin were measured by ELISA. Homeostasis Model Assessment (HOMA) is an arithmetic way of deriving indices of pancreatic endocrine function (beta cell function, HOMA-B) and peripheral tissue insulin sensitivity (HOMA-S) were calculated from fasting plasma samples.
Results:
In diabetic group BMI and waist circumference were significantly increase (p<0.0001& p=0.026). Insulin and leptin were significantly increase (p<0.0001) while, ghrelin was significantly decrease (p<0.0001). HOMA-S, significantly decrease (p=0.0110) while, HOMA-B non significantly increase. There was a negative correlation between plasma ghrelin and BMI (p=0.0149), waist circumference (p=0.0002), SBP and DBP (p<0.0001) while leptin showed significantly positive correlated with BMI and waist circumference (p<0.0001). There was a negative correlation between plasma ghrelin and FBS (p=0.0005), PPBS (p<0.0001), and HOMA-B (p=0.0336) with positive correlation with HOMA-S (p<0.0001), while leptin showed significant positive correlation with HOMA-B (p=0.0023) and significant negative correlation with HOMA-S (p<0.0001). There was a significant negative correlation between plasma ghrelin and serum triglyceride (p<0.001) and LDL cholesterol (p<0.0001) with a positive correlation with HDL cholesterol (p<0.0001) while leptin showed significant positive correlation with serum triglyceride (p=0.0020) and LDL cholesterol (p<0.0001) and significant negative correlation with HDL cholesterol (p<0.0001). There was a negative correlation between plasma ghrelin and insulin and leptin (p<0.0001) with a positive correlation between insulin and leptin (p< 0.0001).
Conclusion: It is suggested that there is interaction between insulin and leptin hormones. Insulin has stimulatory trophic effect on leptin secretion, but the effect of leptin on insulin is controversial as leptin lowers insulin secretion and in the same time modulates insulin action and participates in the development of insulin resistance. It is speculated also that both insulin and leptin have inhibitory role on ghrelin level. Decreased plasma levels of ghrelin are significantly associated with abdominal adiposity, hyperinsulinemia and insulin resistance in type 2 diabetic patients. These hormonal changes are associated with clusters of metabolic abnormalities which are major CHD risk factors. |
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ISSN |
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8832-1012 |
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Journal Name |
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Benha medical journal Sept. |
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Volume |
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24 |
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Issue Number |
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3 |
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Publishing Year |
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2007 AH
2007 AD |
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Article Type |
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Article |
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Added Date |
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Wednesday, March 17, 2010 |
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Researchers
| خالد عظام | ezam, khaled | Researcher | Doctorate | |
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