Document Details Document Type : Article In Journal  Document Title : Growth hormone for children with chronic renal failure and on dialysis. هرمون النمو للأطفال ذوي القصور الكلوي المزمن ، وعلى غسيل الكلى   Document Language : English  Abstract : We studied all children with CRF who received recombinant human growth hormone (rhGH) for more than a year (mean+/-SD duration of therapy 3.7+/-2.5 years) over an 11-year period. There were 32 children. Twenty-one children were conservatively managed, with a mean glomerular filtration rate (GFR) of 24+/-12 mL min(-1)/1.73 m2 at the start of rhGH. Their height standard deviation score improved from -2.5+/-1.4 to -2.1+/-0.7 at 1 year (P=0.3), -2.0+/-0.7 at 2 years (P=0.01), and -1.6+/-0.6 at 3 years (P=0.001). After that there was no improvement. Eleven children were on dialysis, six on haemodialysis (HD) and five on peritoneal (PD). Ht SDS improved from -2.7+/-0.5 to -2.3+/-0.5 at 1 year (P=0.02). Thereafter there was no further improvement. RhGH was stopped because of transplantation in 29 patients at a mean+/-SD age of 12.1+/-4.0 years. Mean Ht SDS was -1.8+/-0.8 at transplant and there was no change over the following 5 years. In conclusion, treatment with rhGH resulted in improvement in Ht SDS in conservatively managed CRF for up to 3.0 years and for 1 year in children on dialysis. Discontinuation of rhGH after transplantation resulted in little change in Ht SDS.  ISSN : 0379-5284  Journal Name : Pediatr Nephrol.  Volume : 5  Issue Number : 20  Publishing Year : 2005 AH 2005 AD  Article Type : Article  Added Date : Wednesday, March 10, 2010  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email جميلة قاري Kari, Jameela Researcher Doctorate   Files File Name Type Description  25864.doc doc   Back To Researches Page