Document Details

Document Type : Article In Journal 
Document Title :
Effect of itraconazole and terbinafine of leishmania major lesions in BALB/c mice
تاثير عقاري اتراكونازول وتيربينافين على قرح الليشمانيا العظيمة في الفئران
 
Subject : Leishmania 
Document Language : English 
Abstract : The effects of two antifungal compounds, the azole itraconazole and the allylamine terbinafine, on Leishmania major infections in mice are reported. Sixty BALB/c mice were each inoculated subcutaneously with metacyclic promastigotes of L. major at the base of the tail. From 4 weeks post-inoculation, 40 of the mice were treated for 4 weeks (20 with itraconazole and 20 with terbinafine) and the rest were left untreated. Lesion sizes were estimated weekly for 10 weeks post-infection. Both drugs appeared effective in treating the cutaneous lesions but response to itraconazole was faster and, at the end of the experiment, the mean size of the lesions on the mice treated with itraconazole was smaller than that of the lesions on the terbinafine-treated mice. 
ISSN : 1364-8594 
Journal Name : Annals of Tropical Medicine & Parasitology 
Volume : 94 
Issue Number : 1 
Publishing Year : 1421 AH
2000 AD 
Article Type : Article 
Added Date : Tuesday, February 23, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
هيثم أحمد زكائيZakai, Haytham AhmedInvestigatorDoctoratehzakai@kau.edu.sa
سمير خضر زموZimmo, Sameer KhedrResearcherDoctorate 

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