Document Details

Document Type : Article In Journal 
Document Title :
Effect of itraconazole and terbinafine on leishmania promastigotes
تاثير عقاري اتراكونازول وتيربينافين على الطور السوطي لطفيل الليشمانيا
 
Subject : Leishmania 
Document Language : English 
Abstract : The antiproliferative effect induced in vitro by two antifungal compounds, the azole itraconazole and the allylamine terbinafine on Leishmania major, L. donovani and L. mexicana promastigotes are reported. Treatment of promastigotes cultures with itraconazole or with terbinafine induced growth arrest with L. major but neither with L. donovani nor with L. mexicana. Concentrations of 0.75 microl/l or more of itraconazole induced cell lysis after 72 hours with L. major. However, even relatively large concentrations of terbinafine (2.0 microl/l) did not induce cell lysis. For L. major, the IC 50 for itraconazole and terbinafine were 0.31 microl/l and 3.3 microl/l respectively. 
ISSN : 1110-0583 
Journal Name : Journal of the Egyptian Society for Parasitology 
Volume : 23 
Issue Number : 1 
Publishing Year : 1423 AH
2003 AD 
Article Type : Article 
Added Date : Tuesday, February 23, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
هيثم أحمد زكائيZakai, Haytham AhmedInvestigatorDoctoratehzakai@kau.edu.sa
سمير خضر زموZimmo, Sameer KhedrResearcherDoctorate 
محمود فؤادFuoad, Mahmoud ResearcherDoctorate 

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