Document Details Document Type : Article In Journal  Document Title : HERPES SIMPLEX VIRUS TYPE 2 (HSV -2) PROTEINS IN ORAL HERPES SIMPLEX VIRUS TYPE 2 (HSV -2) PROTEINS IN ORAL   Document Language : English  Abstract : The present study was conducted in an attempt to search for possible presence of HSY -2 protein in 21 lesional tissues of oral squamous cell carcinoma, as well as in normal oral mucosa, using immunohistochemical peroxidase-antiperoxidase (PAP) technique. Specimens of normal oral mucosa revealed frequent positive staining for polyclonal HSY-2 protein marker thus indicating that HSY -2 is not an uncommon inhabitant of the oral mucosa. Only highly differentiated grades of oral squamous cell carcinoma showed positive staining for HSY -2, while less differentiated carcinomas failed to reveal any immunoreactivity. This raised the suggestion of a possible causative role played by HSY-2 in the establishment of the neoplastic process in oral squamous cell carcinoma through a "hit and run" mechanism. Verrucous carcinoma showed deep intra- epithelial blister formation containing positively-stained koilocytes for the HSY -2 marker. The present results point to HSY -2 as a promoter or an initiator in early neoplastic changes in well differentiated oral squamous cell carcinoma that becomes denatured and consequently not evident in less highly differentiated tumours.  ISSN : 0070-9484  Journal Name : cairo dental journal  Volume : 13  Issue Number : 2  Publishing Year : 1997 AH 1997 AD  Article Type : Article  Added Date : Friday, October 30, 2009  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email عزة السيسي elsisi, azza Investigator Doctorate   Files File Name Type Description  23639.pdf pdf   Back To Researches Page