Document Details

Document Type : Project 
Document Title :
Knowledge of the genetic basis for patients with arthritis using genetic analysis [IL-Ia] in Saudi patients.
معرفة الأسس الجينية لمرضى الروماتيزم باستخدام التحاليل الجينية [IL-Ia] في المرضى السعوديين.
 
Document Language : Arabic 
Abstract : This is the first project of its kind in the Kingdom of Saudi Arabia, where the main objective is to establish a genetic (hereditary) for arthritis arthritis (RA) and the possibility of using (SNPs) likely to compound the IL-1 many forms mono Alnyukluotaad as an indicator for therapeutic intervention early in infection rheumatoid arthritis. This is due to the fact that the offer clinical disease rheumatoid arthritis has become common among Saudi citizens and has conducted many clinical studies, which included attempts Pharmaceutical different, but it did not exist until now reports on the basics lining the inflammatory disease rheumatoid arthritis in Saudi Arabia. During the four and twenty month past, has been a very important part for this project in the unity of Genomic Medicine (GMU) in the King Fahd Center for Medical Research (KFMRC) was established to bring a sample with the Saudis rheumatoid arthritis (n = 100) were divided according to standards of ARA and assembly the same number of members of non-infected (normal controls) of the population of Saudi native who were classified as genetically for a compound of the IL-1 many forms mono Alnyukluotaad include the-IL1A +4845, IL-IB-511, IL-IB-3953 & IL-RA + 2016 In this study, the situation arose where arbitrary significant relationship (P = 0.0009) between the genes for rare genetic composite IL-BI +3953 and symptoms infected with rheumatoid arthritis. The pregnancy of these genes is equal to 18% higher in the infected group for this polymorphism to the healthy group controlled, with a relationship that did not arise sharply. Been adapted based methods PCR-RFLP composite art was extracted acid Aldiuksy Rayboniocliq lower level using genomic technology fund small column of QIAGEN of all patients and samples of individuals to control. The product analysis was limited to the proportion of 9-12% of the gel using the appropriate parameters of the nucleic acid DNA. So I recommend that this project should continue with the affected households that have been discussed and should increase the strength of the study to increase the number of samples. That day is not far away, where instead of an analysis technique IL-1-dependent technique ELISA in patients with true rheumatoid arthritis in Saudi Arabia to the families affected will have the image genome of composite IL-1, which were early and were used as indicators for therapeutic intervention fast. 
Publishing Year : 1422 AH
2002 AD 
Sponsor Name : kau 
Sponsorship Year : 1422 AH
2002 AD 
Added Date : Wednesday, April 30, 2008 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عديل جلزار شودريchaudhary, adeel gulzarInvestigatorDoctorate 

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